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Jie Cheng, MD, PhD
Professor of Medicine
Director, Cardiac
Electrophysiology Research Laboratory
Texas Heart Institute/St.
Luke's Episcopal Hospital
Director, Cardiac Electrophysiology Institute
University of Texas School of Medicine at Houston
6770 Bertner Ave MC2-255
Houston, TX 77030
e-mail: jcheng@heart.thi.tmc.edu
Google Scholar: http://scholar.google.com/citations?user=ptwYq6YAAAAJ
Dr. Jie Cheng graduated
from the Shanghai Second Medical University in Shanghai China in 1982
and went on to earn a Master of Science and Doctor of Philosophy at
the Case Western Reserve University (CWRU) in Cleveland Ohio where he
majored in Biomedical Engineering between 1983 and 1988. His
dissertation project was on the mathematical modelling of
atrioventricular conduction. After completion of his formal
education, Dr. Cheng spent 3 years in basic science research as a
recipient of an Individual Research Service Award from the National
Institute of Health before he began clinical residency training in
Internal Medicine (1991-1994 at the Mt. Sinai Medical Center in
Cleveland), fellowship in Cardiology (1994-1996 at the University of
Chicago) and fellowship in Cardiac Eletrophysiology (1996-1998 at the
University of California San Francisco). Currently he serves as the
Director of the Cardiac Electrophysiology Research Laboratory at the
Texas Heart Institute and Director and Professor of Cardiac
Electrophysiology Institute of University of Texas School of Medicine
at Houston.
His major research
interests are innovative therapy for complex cardiac arrhythmias and
basic understanding of the mechanisms underlying these arrhythmias.
His contribution to the field of cardiac arrhythmias has been well
recognized internationally. In recent years, his basic science
research laboratory has focused its effort on the molecular and
cellular mechanisms by which the neuronally released polypeptides act
on the electrophysiological properties of the heart.
程杰，
医学博士
贝勒医学院临床教授
圣卢克主教医院德州心脏中心心脏电生理研究室主任
德州休士顿
程杰博士于1982年毕业中国上海第二医科大学，随后于1983至1988年间，在位于俄亥俄州克利夫兰的凯斯西储大学攻读生物医学科学硕士学位和
博士学位。他的博士课题是研究基于数学模型的房室传导。此后，在他开始临床住院医师培训之前，他在美国国家研究院的“国家个人研究服务奖”基金的支助下， 开展了为期三年的基础研究。他分别在完成了内科住院医师（1991-1994年 在克里夫兰西奈山医疗中心），心血管内科专科医师（1994-1996
在芝加哥大学），心脏电生理专科医师（1996-1998加利福尼亚大学 旧金山分校）的培训。目前任职于贝勒医学院临床副教授，德州心脏中心心脏电生理研究室主任。
他的临床主要研究方向是复杂性心律失常的革新治疗和基础机制研究。他在心律失常领域的贡献已得到本领域的国际认可。今年来，他的基础研究主要集中于神经多肽在心脏电生理特性中的分子细胞学作用。
List of selected
publications
- Yang T, Cheng J, and Levy MN:
Effects of spatial dispersion of acetylcholine release on the
chronotropic responses to vagal stimulation in dogs. Circ.
Res. 67:844-851, 1990. PMID: 2208610
- Cheng J, and Scheinman MM:
Charateristics of double-wave reentry induced by programmed
stimulation in patients with typical atrial flutter. Circulation
97:1589-1596, 1998. PMID: 9593564
- Cheng J, Cabeen WR Jr, and
Scheinman MM: Right atrial flutter due to lower-loop reentry:
mechanism and anatomic substrate. Circulation 99:1700-1705,
1999. PMID: 10190879
- Glatter KA, Cheng J, Dorostkar
PC, Modin G, Talwar S, Al-Nimri M, Lee RJ, Saxon LA, Lesh MD,
Scheinman MM: Electrophysiologic effects of adenosine in
patients with supraventricular tachycardia. Circulation
99:1034-1040, 1999. PMID: 10051297
- Yang Y, Cheng
J,
Bochoeyer
A, Hamdan
MH,
Kowal
RC,
Page
R, Lee
RJ,
Steiner
PR,
Saxon
LA,
Lesh
MD,
Modin
GW,
Scheinman
MM:
Atypical right atrial flutter patterns. Circulation,
103(25):3092-3098, 2001. PMID: 11425774
- Cheng J, Glatter KA, Yang
YF, Zhang S, Lee RJ and Scheinman MM: Electrophysiological
Response of the Right Atrium to Ibutilide During Typical Atrial
Flutter. Circulation 106:814-819, 2002. PMID: 12176953
- Zhang SL, Younis G, Gao LJ, Yang Y,
Ip J, Thakur RK, Scheinman MM, Cheng J: Lower loop
reentry as a mechanism of clockwise right atrial flutter.
Circulation 6;109(13):1630-5, 2004. PMID: 15037534
- Cheng J, Yang Y, Ursell PC,
Lee RJ, Dorostkar PC, Boahene KA, Scheinman: Protected
circumferential conduction in the posterior atrioventricular
vestibule of the left atrium: electrophysiologic and anatomic
correlates. Pacing Clin Electrophysiol. Jul;28(7):692-701, 2005.
PMID: 16008806
- Shuraih M, Ai T, Vatta M, Sohma Y,
Merkle EM, Taylor E, Li Z, Razavi M, Towbin JA, Cheng J:
A common SCN5A variant alters the responsiveness of human sodium
channels to class I antiarrhythmic agents. J Cardiovasc
Electrophysiol. 2007;18(4):434-40. PMID: 17331104
- Yang DH, Xi Y, Ai T, Wu G, Sun JP,
Razavi M, Delapasse S, Shurail M, Gao L, Mathuria N, Elayda M
and Cheng J: Vagal
stimulation promotes atrial electrical remodeling induced by
rapid atrial pacing in dogs: evidence of a noncholinergic
effect. Pacing Clin Electrophysiol. 2011; 34(9):1092–1099. PMID:
21793861
- Xi Y, Ai T, De Lange E, Li Z, Wu G,
Brunelli L, Kyle WB, Turker I, Cheng J, Ackerman MJ, Kimura
A, Weiss JN, Qu Z, Kim JJ, Faulkner G, Vatta M. Loss-of-Function
of hNav1.5 by ZASP1-D117N Associated with Intraventricular
Conduction Disturbances in Left Ventricular Noncompaction. Circ
Arrhythm Electrophysiol. 2012; 5(5):1017-26.
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