CAAC Co-Chair of BOT and Membership Review Committee

 

Lei Xiao, MD, PhD

Assistant Professor of Medicine (Tenure-Track)

Director for Research Education (Section of PCCSA)
Department of Medicine & Center for Cardiovascular Research
University of Illinois at Chicago, College of Medicine
840 S Wood St, M/C: 719

Chicago, IL 60612

Dr. Lei Xiao graduated from Peking University Health Science Center (Beijing, China) in 1993 with a major in Clinical Medicine. He received his Ph.D. in Pharmacology from Creighton University School of Medicine (Omaha, NE) in 1998, where he first cloned the mouse α_1A-adrenergic receptor gene during his Ph.D. studies. In June 2001, he completed his postdoctoral fellow training in cardiovascular diseases in the Division of Cardiology at Boston University School of Medicine (Boston, MA), where he then stayed on faculty, and soon became an Assistant Professor of Medicine in Division of Cardiology. In 2004, Dr. Xiao relocated his lab to the University of Illinois at Chicago (UIC, Chicago, IL), and joined in the Department of Medicine (Sections of Pulmonary, Critical Care, Sleep and Allergy; & Cardiology), and the Center for Cardiovascular Diseases.

Currently, Dr. Xiao is a tenure-track Assistant Professor of Medicine at UIC. He is also the Director for Research Education in the Section of PCCSA, and is the Principle Investigator (PI) of two NIH R01 grants, one American Heart Association (AHA) National Scientist Development Grant (NSDG), and several other intramural research grants. He is also the Co-investigator of three NIH R01 grants and three NIH S10 grants with other PI's. The research interests of Dr. Xiao's lab focus on the role of NADPH oxidase and reactive oxygen species in cardiac hypertrophy and heart failure, as well as the signal transduction pathways in cardiac myocytes and macrophages.

Dr. Xiao has received over 15 national and international awards for his research achievement. In 1999 and 2000, he received the First Place Award two years in a row at the annual AstraZeneca New England Cardiovascular Research Competition. In 2001, he was awarded the prestigious Jay N. Cohn New Investigator Award from the Heart Failure Society of America (HFSA). He is a member of the AHA and the American Society for Pharmacology & Experimental Therapeutics (ASPET), and received the BCVS Travel Grant Award from the AHA Council on Basic Cardiovascular Sciences (BCVS) in 2011. Dr. Xiao has served as an editor or a reviewer for 17 academic journals including Circulation and Circ. Res., and also as a study section member or grant reviewer for multiple research funding agencies including Veterans Affairs (VA) Merit Grant Review Cardiovascular Study Section.

ten Selected Journal Articles (From Over 80 Publications):

1.     Liu Y, Lou YQ, Liu K, Liu JL, Wang ZG, Wen J, Zhao Q, Wen SJ, Xiao L: Role of Leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case-control association study in a Northern Han Chinese population. J Hum Hypertens, doi:10.1038/jhh.2013.149, Epub Feb. 13, 2014. PMID: 24522342

2.     DeSantiago J, Bare DJ, Xiao L, Ke Y, Solaro RJ, Banach K. p21-Activated kinase1 (Pak1) is a negative regulator of NADPH-oxidase 2 in ventricular myocytes. J. Mol. Cell. Cardiol. 67:77-85, 2014. PMID: 24380729

3.Sovari AA, Rutledge CA, Jeong EM, Dolmatova E, Arasu D, Liu H, Vahdani N, Gu L, Zandieh S, Xiao L, Bonini MG, Duffy HS, Dudley SC: Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death, Circ Arrhythm Electrophysiol, 6:623-631, 2013. PMID: 23559673

4.Zhao G, Yu R, Deng J, Zhao Q, Christman JW, van Breemen RB, Xiao L: Pivotal role of reactive oxygen species in regulating lipopolysaccharide-induced prostaglandin D₂ production in macrophages. Mol Pharmacol, 83(1):167-78, 2013. PMID: 23071105

5.    Xiao L, Zhao Q, Du Y, Chao Y, Solaro RJ, Buttrick PM: PKCε increases phosphorylation of cardiac myosin binding protein C at serine302 both in vitro and in vivo. Biochemistry 46(23):7054-7061, 2007

6.    Maytin M, Siwik DA, Ito M, Xiao L, Sawyer DB, Liao R, Colucci WS.: Pressure overload-induced myocardial hypertrophy in mice does not require gp91^phox. Circulation 109(9):1168-71, 2004.

7.    Xiao L, Pimentel DR, Wang J, Singh K, Colucci WS, Sawyer DB: Role of reactive oxygen species and NAD(P)H oxidase in α₁-adrenoceptor signaling in adult rat cardiac myocytes. Am J Physiol Cell Physiol, 282:C926-C934, 2002.

8.    Xiao L., Pimental D.R., Amin J.K., Singh K., Sawyer D.B., Colucci W.S.: MEK1/2-ERK1/2 mediates α₁-adrenergic receptor stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33:779-787, 2001.

9.    Amin JK, Xiao L, Pimental DR, Patrick PJ, Sawyer DB, Colucci WS: Reactive oxygen species mediate alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33:131-139, 2001.

10.  Pimentel DR, Amin JK, Xiao L, Miller T, Viereck J, Oliver-Krasinski J, Baliga R, Wang J, Siwik DA, Singh K, Pagano P, Colucci WS, Sawyer DB: Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ. Res. 89:453-460, 2001.