Ruihai Zhou, MD, FACC

Department of Cardiology

Caldwell Memorial Hospital

University of North Carolina Health Care

Adjunct assistant professor

Department of Medicine

University of North Carolina at Chapel Hill

 

 

SPECIALTY/ Board certifications:

1.      Internal Medicine, American Board of Internal Medicine

2.      Cardiovascular Disease, American Board of Internal Medicine

3.      Interventional Cardiology, American Board of Internal Medicine

4.      Registered Physician in Vascular Interpretation (RPVI), American Registry for Diagnostic Medical Sonography

 

CLINICAL INTERESTS:

1.      Prevention, diagnosis, and treatment of cardiovascular and peripheral vascular diseases

2.      Cardiac catheterization

3.      Percutaneous intervention (angioplasty and stenting) for the treatment of coronary artery disease

4.      Percutaneous intervention (angioplasty and stenting) for the treatment of peripheral vascular disease including upper and lower extremities and renal artery disease, among others

 

Education/professional training/work experiencE:

8/2014-present   General and interventional cardiologist, Robbins Cardiology, Caldwell Memorial Hospital, University of North Carolina Health Care

5/2014-present   Adjunct assistant professor, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill

7/2013-6/2014    Interventional Cardiology fellowship, University of North Carolina at Chapel Hill School of Medicine

7/2009-6/2013    Clinical Cardiology/Physician Scientist fellowship, University of North Carolina at Chapel Hill School of Medicine

6/2006-6/2009    Medical resident (internal medicine), Greenwich Hospital/Yale University School of Medicine

7/2005-6/2006    Instructor (faculty, translational medicine in cardiovascular disease), The Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA

7/2004-6/2005    Postdoctoral researcher (translational medicine in cardiovascular disease), The Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA

6/2001-6/2004    Postdoctoral researcher (cardiovascular biomedical research), Division of Biomedical Sciences, University of California, Riverside, CA

2/2001-6/2001    Attending physician (internal medicine/geriatrics), Shandong University Qilu Hospital, China

1/1999-2/2001    Japan Science and Technology Agency (STA) Fellowship Awardee scientist (molecular and genetic cardiovascular research), National Cardiovascular Center, Osaka, Japan

10/1992-1/1999  Attending physician (internal medicine/geriatrics), Shandong University Qilu Hospital, China

9/1991-10/1992  Medical scholarship awardee scientist (clinical pharmacology and therapeutics), Oita Medical University, Japan (Japan Sasagawa Medical Scholarship)

7/1988-8/1991    Medical resident-attending physician (internal medicine), Shandong University Qilu Hospital, China

8/1985-7/1988    MSc, Pharmacology, School of Medicine, Shandong University, China

9/1980-7/1985    MD, Binzhou Medical College, Shandong, China

 

medical Licensure: North Carolina

 

LANGUAGES: English, Chinese, and Japanese

 

Honors/AWARDs:

 

1.      Japan Sasagawa Medical Scholarship (clinical pharmacology and therapeutics), 10/1991-9/1992

2.      Japan Government Science & Technology Agency (STA) Fellowship (molecular and genetic cardiovascular research), 1/1999-2/2001

3.      American Heart Association Grant-in-Aid, 07/01/2006-06/31/2008. Role of Sterol Response Element-binding Protein in Postintervention Vascular Restenosis. (AHA ID #:0665450U)

4.      Resident Teacher of The Year (the only awardee of the year), Greenwich Hospital/Yale University School of Medicine, 6/2009

5.      Grant-in-aid from National Natural Science Foundation of China. Role of sterol response element-binding protein in the molecular control of angiogenesis in endothelial cells. Jan, 2005.1-Dec 2007 (No.30471920, by Chinese Government)

6.      Grant-in-aid from National Natural Science Foundation of China 2000-2003. Cloning and characterization of human brain- and heart-specific gene NDRG. (No. 30070305, by Chinese Government)

 

Selected publications (in chronological order, conference presentations or abstracts not listed):

1)            Zhou RH, Kimiko Tsutsumi, and Shigeyuki Nakano. Effects of isolation housing and timing of drug administration on theophylline kinetics in mice. Japanese Journal of Pharmacology. 1992 Nov; 60(3):287-289

2)            Zhou RH, Bin Xi, Hai-Qing Gao, et al. Circadian and septadian variation in the occurrence of acute myocardial infarction in a Chinese population. Japanese Circulation Journal. 1998 Mar; 62(3):190-192

3)            Zhou RH, Qing Shi, Hai-Qing Gao, Bai-Jun Shen. Changes in serum interleukin-8 and interleukin-12 levels in patients with ischemic heart disease in a Chinese population. Journal of Atherosclerosis and Thrombosis. 2001; 8(1): 30-32

4)            Zhou RH, Kokame K, Tsukamoto Y, et al. Characterization of the human NDRG gene family: A newly identified member, NDRG4, is specifically expressed in brain and heart. Genomics, 2001 Apr; 73(1):86-97

5)            Zhou RH, Lee T-S, Tsou T-C, Rannou F, et al. Stent Implantation Activates Akt in the Vessel Wall. Role of Mechanical Stretch in Vascular Smooth Muscle Cells.  Arteriosclerosis Thrombosis and Vascular Biology. 2003 Sept; 23(11):2015-20

6)            Rannou F, Lee T-S, Zhou RH, Chin Jennie, Lotz JC, Mayoux-Benhamou Marie-Anne, Barbet Jacques Patrick, Chevrot Alain, and Shyy JYJ. Intervertebral disc degeneration: The role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. American Journal of Pathology, 2004 Mar; 164(3): 915-924

7)            Zhou RH, Min Yao, Tzong-Shyuan Lee, Yi Zhu, Manuela Martins-Green, John Y.-J. Shyy. Vascular endothelial growth factor activation of sterol regulatory element binding protein: A potential role in angiogenesis. Circulation Research. 2004 July; 95:471-478

8)            Zhou RH*(Co-1st author), Keys JR*, Harris DM, et al. Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling. Circulation. 2005 Aug; 112:1145-1153

9)            Pleger ST, Remppis A, Heidt B, V�lkers M, Chuprun JK, Kuhn MC, Zhou RH, Gao E, Szabo G, Weichenhan D, M�ller OJ, Eckhart AD, Katus HA, Koch WJ and Most P. S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Molecular Therapy. 2005 Dec; 12:1120-9

10)        Yao M, Zhou RH, Petreaca M, Zheng L, Shyy J, Martins-Green M. Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis. The Journal of Leukocyte Biology. 2006 Sep; 80(3):608-620

11)        Qiu J, Gao HQ, Zhou RH, Liang Y, Zhang XH, Wang XP, You BA, Cheng M. Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biological & Pharmaceutical Bulletin. 2007 Feb; 30(2):247-253

12)        Gao E, Boucher M, Chuprun JK, Zhou RH, Eckhart AD, Koch WJ. Darbepoetin alpha, a long-acting erythropoietin analogue, offers novel and delayed cardioprotection for the ischemic heart. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1): H60-68

13)        Harris DM, Cohn HI, Pesant S, Zhou RH, Eckhart AD. Vascular smooth muscle Gq signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension. Am J Physiol Heart Circ Physiol. 2007 Sept; 293(5): H3072-9

14)        Zhou RH, Pesant S, Cohn H, Druckman C, Mandel E, Eckhart AD. Enhanced sterol response element-binding protein in postintervention restenotic blood vessels plays an important role in vascular smooth muscle proliferation. Life Sciences, 2008 Jan; 82(3-4):174-81

15)        Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ, Dorn Ii GW, Eckhart AD. Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1695-704

16)        Qiu J, Gao HQ, Liang Y, Yu H, Zhou RH. Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells. Biochim Biophys Acta. 2008 Nov; 1784(11): 1857-64

17)        Zhou RH, Pesant S, Cohn H, Soltys S, Koch WJ, Eckhart AD. Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5. Clinical and Translational Science. 2009 Feb; 2(1): 57-61

18)        Zhou RH, Frishman WH. The anti-platelet effect of nitrates: Is it of clinical benefit in patients with cardiovascular disease? (Invited review). Cardiology in Review. 2010 July/Aug;18(4): 198-203

19)        Madamanchi NR, Zhou RH, Vendrov AE, Niu XL, and Runge MS. Does Oxidative DNA Damage Cause Atherosclerosis and Metabolic Syndrome?: New Insights Into Which Came First: The Chicken or the Egg. Circ Res 2010 Nov;107: 940-942

20)        Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou RH, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G. Impaired neoangiogenesis in β(2)-adrenoceptor gene-deficient mice: restoration by intravascular human β(2)-adrenoceptor gene transfer and role of NFκB and CREB transcription factors. Br J Pharmacol. 2011 Feb;162(3):712-21

21)        Li B-Y, Li X-L,  Cai Q, Gao H-Q, Cheng M, Zhang J-H, Wang J-F, Yu F, Zhou RH. Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol. Apoptosis. 2011; July 16(7):732�745

22)        Yu F, Li BY, Li XL, Cai Q, Zhang Z, Cheng M, Yin M, Wang JF, Zhang JH, Lu WD, Zhou RH, Gao HQ. Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage. PLoS One. 2012;7(12):e52541

23)        Zhou RH, Vendrov AE, Tchivilev I, Niu X-L, Molnar KC, Rojas M, Stouffer GA, Madamanchi NR, Runge MS. Mitochondrial oxidative stress in aortic stiffening with age: The role of smooth muscle cell function. Arteriosclerosis Thrombosis and Vascular Biology. 2012 Mar 32(3):745-55

24)        Zhang Z, Li BY, Li XL, Cheng M, Yu F, Lu WD, Cai Q, Wang JF, Zhou RH, Gao HQ, Shen L. Proteomic analysis of kidney and protective effects of grape seed procyanidin B2 in db/db mice indicate MFG-E8 as a key molecule in the development of diabetic nephropathy. Biochim Biophys Acta. 2013 Jun;1832(6):805-16.

25)        Li XL, Li BY, Cheng M, Yu F, Yin WB, Cai Q, Zhang Z, Zhang JH, Wang JF, Zhou RH, Gao HQ. PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. PLoS One. 2013 Jul 26;8(7):e69979.

26)        Zhou RH, Stouffer GA. Is time of renal hypoperfusion an important variable in determining response to renal artery revascularization? JACC Cardiovasc Interv. 2014 Jan; 7(1):110

27)        Yin W, Li B, Li X, Yu F, Cai Q, Zhang Z, Wang J, Zhang J, Zhou R, Cheng M, Gao H. Critical role of prohibitin in endothelial cell apoptosis caused by glycated low-density lipoproteins and protective effects of grape seed procyanidin B2. J Cardiovasc Pharmacol. 2015 Jan;65(1):13-21